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Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions.
Guo T, Zhang L, Chang NE, Singer S, Maki RG, Antonescu CR. Guo T, et al. Genes Chromosomes Cancer. 2011 Jan;50(1):25-33. doi: 10.1002/gcc.20827. Genes Chromosomes Cancer. 2011. PMID: 20949568 Free PMC article.
High-level MYC amplification was found in 100% of secondary AS, but in none of the AVL or other radiation-associated sarcomas. ...Our findings reinforce the distinct pathogenesis of AS subtypes, with MYC amplification being an early, but necessary event in secondary …
High-level MYC amplification was found in 100% of secondary AS, but in none of the AVL or other radiation-associated sarcomas. ...Our …
Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome.
Choschzick M, Lassen P, Lebeau A, Marx AH, Terracciano L, Heilenkötter U, Jaenicke F, Bokemeyer C, Izbicki J, Sauter G, Simon R. Choschzick M, et al. Mod Pathol. 2010 Apr;23(4):603-10. doi: 10.1038/modpathol.2010.5. Epub 2010 Feb 5. Mod Pathol. 2010. PMID: 20139910 Free article.
Copy number gains involving the long arm of chromosome 8, including high-level amplifications at 8q21 and 8q24, have been frequently reported in breast cancer. Although the role of the MYC gene as the driver of the 8q24 amplicon is well established, the significance of the …
Copy number gains involving the long arm of chromosome 8, including high-level amplifications at 8q21 and 8q24, have been frequently reporte …
Genetic markers associated with early cancer-specific mortality following prostatectomy.
Liu W, Xie CC, Thomas CY, Kim ST, Lindberg J, Egevad L, Wang Z, Zhang Z, Sun J, Sun J, Koty PP, Kader AK, Cramer SD, Bova GS, Zheng SL, Grönberg H, Isaacs WB, Xu J. Liu W, et al. Cancer. 2013 Jul 1;119(13):2405-12. doi: 10.1002/cncr.27954. Epub 2013 Apr 22. Cancer. 2013. PMID: 23609948 Free PMC article.
These included gains of chromosomal regions that contain the genes MYC, ADAR, or TPD52 and losses of sequences that incorporate SERPINB5, USP10, PTEN, or TP53. On multivariate analysis, only the CNAs of PTEN (phosphatase and tensin homolog) and MYC (v-myc …
These included gains of chromosomal regions that contain the genes MYC, ADAR, or TPD52 and losses of sequences that incorporat …
Epigenetic silencing of miR-145-5p contributes to brain metastasis.
Donzelli S, Mori F, Bellissimo T, Sacconi A, Casini B, Frixa T, Roscilli G, Aurisicchio L, Facciolo F, Pompili A, Carosi MA, Pescarmona E, Segatto O, Pond G, Muti P, Telera S, Strano S, Yarden Y, Blandino G. Donzelli S, et al. Oncotarget. 2015 Nov 3;6(34):35183-201. doi: 10.18632/oncotarget.5930. Oncotarget. 2015. PMID: 26440147 Free PMC article.
Down-regulation was attributed to methylation of miR-145's promoter and affiliated elevation of several protein targets, such as EGFR, OCT-4, MUC-1, c-MYC and, interestingly, tumor protein D52 (TPD52). In line with these observations, restored expression of miR-145- …
Down-regulation was attributed to methylation of miR-145's promoter and affiliated elevation of several protein targets, such as EGFR, OCT-4 …
DNA copy number changes at 8q11-24 in metastasized colorectal cancer.
Buffart TE, Coffa J, Hermsen MA, Carvalho B, van der Sijp JR, Ylstra B, Pals G, Schouten JP, Meijer GA. Buffart TE, et al. Cell Oncol. 2005;27(1):57-65. doi: 10.1155/2005/401607. Cell Oncol. 2005. PMID: 15750208 Free PMC article.
BACKGROUND: C-Myc, a well-known oncogene located on 8q24.12-q24.23, is often amplified and over-expressed in both primary and metastasizing colorectal cancer. ...Most of the liver metastases showed higher DNA copy number ratios than the corresponding primary tumors, but th …
BACKGROUND: C-Myc, a well-known oncogene located on 8q24.12-q24.23, is often amplified and over-expressed in both primary and metasta …
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study.
Ross-Adams H, Lamb AD, Dunning MJ, Halim S, Lindberg J, Massie CM, Egevad LA, Russell R, Ramos-Montoya A, Vowler SL, Sharma NL, Kay J, Whitaker H, Clark J, Hurst R, Gnanapragasam VJ, Shah NC, Warren AY, Cooper CS, Lynch AG, Stark R, Mills IG, Grönberg H, Neal DE; CamCaP Study Group. Ross-Adams H, et al. EBioMedicine. 2015 Jul 29;2(9):1133-44. doi: 10.1016/j.ebiom.2015.07.017. eCollection 2015 Sep. EBioMedicine. 2015. PMID: 26501111 Free PMC article.
We confirm alterations in six genes previously associated with prostate cancer (MAP3K7, MELK, RCBTB2, ELAC2, TPD52, ZBTB4), and also identify 94 genes not previously linked to prostate cancer progression that would not have been detected using either transcript or copy num …
We confirm alterations in six genes previously associated with prostate cancer (MAP3K7, MELK, RCBTB2, ELAC2, TPD52, ZBTB4), and also …
Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis.
Kazmi SJ, Byer SJ, Eckert JM, Turk AN, Huijbregts RP, Brossier NM, Grizzle WE, Mikhail FM, Roth KA, Carroll SL. Kazmi SJ, et al. Am J Pathol. 2013 Mar;182(3):646-67. doi: 10.1016/j.ajpath.2012.11.017. Epub 2013 Jan 13. Am J Pathol. 2013. PMID: 23321323 Free PMC article.
Array comparative genomic hybridization (CGH) demonstrated reproducible chromosomal alterations in P(0)-GGFbeta3 MPNST cells (including universal chromosome 11 gains) and focal gains and losses affecting 39 neoplasia-associated genes (including Pten, Tpd52, Myc, Gli …
Array comparative genomic hybridization (CGH) demonstrated reproducible chromosomal alterations in P(0)-GGFbeta3 MPNST cells (including univ …
[PC-1 enhances c-myc gene expression in prostate cancer cells].
Yu L, Shi QG, Qian XL, Li SH, Wang HT, Wang LL, Zhou JG. Yu L, et al. Yi Chuan. 2010 Apr;32(4):348-52. doi: 10.3724/sp.j.1005.2010.00348. Yi Chuan. 2010. PMID: 20423888 Chinese.
Furthermore, a small-molecule c-Myc inhibitor, 10058-F4 represses PC-1 gene expression in C4-2 cell line. ...Meanwhile, c-myc plays a feed-forward role in enhancing PC-1 driven c-myc gene expression, and promotes prostate an-drogen-independent progression....
Furthermore, a small-molecule c-Myc inhibitor, 10058-F4 represses PC-1 gene expression in C4-2 cell line. ...Meanwhile, c-myc …